Expert Series: Ceramides: The Unmasked Drivers of VLCADD-Induced Heart Failure

March 12, 2025 01:02:47
Expert Series: Ceramides: The Unmasked Drivers of VLCADD-Induced Heart Failure
MitoAction Expert Series
Expert Series: Ceramides: The Unmasked Drivers of VLCADD-Induced Heart Failure

Mar 12 2025 | 01:02:47

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Show Notes

Despite advances in newborn screening and treatment of fatty acid oxidation disorders, patients with very-long-chain acyl-CoA dehydrogenase deficiency (VLCADD) continue to suffer from heart failure. Marie Norris will discuss her preliminary data which suggests that lipotoxicity, largely mediated by the accumulation of ceramides, is a major contributor to VLCADD-induced heart failure. Ms. Norris will discuss the role of ceramides, while addressing the mounting evidence that elevated ceramides contribute to heart failure in humans/rodents and that cardiac function improves with ceramide depletion.

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