Expert Series: Ceramides: The Unmasked Drivers of VLCADD-Induced Heart Failure

March 12, 2025 01:02:47
Expert Series: Ceramides: The Unmasked Drivers of VLCADD-Induced Heart Failure
MitoAction Expert Series
Expert Series: Ceramides: The Unmasked Drivers of VLCADD-Induced Heart Failure

Mar 12 2025 | 01:02:47

/

Show Notes

Despite advances in newborn screening and treatment of fatty acid oxidation disorders, patients with very-long-chain acyl-CoA dehydrogenase deficiency (VLCADD) continue to suffer from heart failure. Marie Norris will discuss her preliminary data which suggests that lipotoxicity, largely mediated by the accumulation of ceramides, is a major contributor to VLCADD-induced heart failure. Ms. Norris will discuss the role of ceramides, while addressing the mounting evidence that elevated ceramides contribute to heart failure in humans/rodents and that cardiac function improves with ceramide depletion.

Other Episodes

Episode

May 19, 2022 01:03:14
Episode Cover

Introducing Bendavia

Join us with Dr. Ben Bronstein and Travis Wilson from Stealth Peptides. Stealth Peptides is a private biotech company responsible for the development of...

Listen

Episode

April 12, 2022 01:22:18
Episode Cover

Multiple Specialists

MitoAction meeting discussing multiple specialists.

Listen

Episode

June 23, 2022 01:08:53
Episode Cover

Cannabis Oil to Treat Mitochondrial Disease

What is the historical use of marijuana for medical purposes? Are there legalities associated with medical marijuana use? When is medical cannabis a potential...

Listen